About the Study

Information About the Study

The aim of this study is to evaluate the clinical and cost-effectiveness of containment surgery compared to best conservative care amongst children aged 5 to 12 years old with Perthes’ Disease.

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  TREATMENT

  In the Op NON-STOP Study (Operative or Non-Surgical Treatment of Perthes’ disease) 
half of the children will receive ‘active containment’ and half will receive ‘surgical containment’.

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  THINGS TO KNOW

  At the end of the study, it will help everyone to know what the best treatment is. To make sure people learn about the best treatment, the doctors who help with this study will talk to other doctors, and other people in the NHS who write national guidelines.

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  PERSONAL DATA

  Personal details will be held by the research team at the University of Oxford. All information that is collected during the course of the research will be used and stored in accordance with the current data protection legislation.

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  STUDY FUNDER

  This study is funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment (NIHR152309).

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  STUDY SPONSOR

  Alder Hey Children’s NHS Foundation Trust is the sponsor 
for Op NON-STOP.

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  STUDY DESIGN

  Op NON-STOP is a multi-
centre prospective randomised superiority trial.

Study Team

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  PROF DAN PERRY

  Chief Investigator

  Dan is an NIHR Research Professor and a consultant in children's orthopaedic surgery.
  He leads international clinical research in a broad array of conditions & injuries that affect children, and loves to ensure that research is presented in a way that is accessible to everyone.

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  MR NICK NICOLAOU

  Joint Lead Grant Applicant

  Nick is a Consultant Paediatric Orthopaedic Surgeon at Sheffield Children’s Hospital.
  He is a founding member of the British Society for Children’s Orthopaedic Surgery (BSCOS), research committee and an opinion leader within BSCOS.

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  LOUISE SPOORS

  Study Manager

  Louise manages a suite of children’s trauma trials at the University of Oxford.
  She was a nurse for many years and has a real understanding of the challenges of doing clinical trials in hospitals.

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  ADAM GALLOWAY

  Adam is an Advanced Practice Children’s Physiotherapist and a NIHR Clinical Doctoral Research Fellow in Leeds.
  He has completed a PhD in Perthes’ Disease, focussing on the therapy-needs of children with Perthes’ Disease and their families.