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OP NON STOP

Welcome to the Op NON-Stop Study

The study will compare the outcomes of 'Active Containment' and 'Surgical Containment' in children treated for Perthes’ Disease.

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Participant Information Animation

  • This study will compare surgical containment with active containment in a group of 216 children with Perthes’ Disease. This animation provides a summary of the study:

  • In the second video below, Professor Dan Perry describes the study in more detail:

Background

Perthes’ Disease is caused by a temporary problem with the blood supply to the hip, which means the ball doesn’t get enough oxygen and nutrients to stay as hard as usual.

This means that the hip ball becomes soft (like a melting ice-cream).

After some months the blood supply returns, and the hip gets hard again. Problems can occur when the hip ball hardens, because it stays whatever shape it became when it was squashy.

This can lead to a hip ball that doesn’t fit well into the hip socket, which can cause pain and stop the child doing their usual activities.

The best time to treat the hip in Perthes’ disease is when the hip is squashy, which is the stage that your child is currently in. Once the hip becomes hard, the treatment options change.

In the UK, about half of the surgeons treat children affected by Perthes’ disease with ‘active containment’.

Active containment is a package of care that involves physiotherapy, activity restriction, education and pain relief.

The specific physiotherapy aims to maintain movement of the hip and keep the soft ball moving within the socket, allowing it to continually smooth its shape – i.e. the ‘ice cream rolling within the scoop’.

The other half of surgeons treat children affected by Perthes’ disease with ‘surgical containment.’ Surgical containment involves an operation to break the bone to re-orientate the hip.

Surgery involves reorientating either the thigh bone (femur) or the hip bone (pelvis). This means that the ‘ice-cream ball’ changes position in the ‘ice cream scoop’, to make the hip squash into the round shape
of the socket.

Aims

The aim of this study is to evaluate the clinical and cost-effectiveness of surgical containment compared to active containment amongst children aged 5 to 12 years old with Perthes’ Disease.

  • STUDY PARTICIPANTS

    Children ages 5 to 12 years old with newly diagnosed Perthes’ Disease.

  • STUDY PERIOD

    Children will be in the study 
for 3 years.

  • SAMPLE SIZE

    At least 216 children aged 5 to 
12 years old.

Taking Part

If you are interested in your child taking part in the study you can find out more in the patient information section:

Participant information site

If you are a HCP you can enrol a patient into the study using RedCap system:

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More Information

Various logos of institutions affiliated with OP Non Stop

Op NON-STOP is funded by the National Institute for Health and Care Research (project number 152309). The views expressed are those of the authors and are not intended to be representative of the views of the funder, sponsor or other participating organisations.

The information contained in this website is for general information about the Op NON-STOP study and is provided by the University of Oxford (Oxford Trauma).